Molecular epidemiology of carbapenem resistance in Acinetobacter baumannii isolates in Shahid Mohammadi Hospital, Bandar Abbas, Iran
Authors
Abstract:
Introduction: Acinetobacter baumannii is a major cause of nosocomial infections which affect mainly disabled patients in intensive care units. The bacteria may acquire resistance to antibiotics and hence can seriously endanger antibiotic therapy. The most important problem facing treatment of A. baumannii is increasing reports of resistance to a wide range of antibiotics, including carbapenems, as the treatment of choice for this bacterial infection. Oxacillinase-type carbapenemases belonging to Class D beta-lactamases (OXA-type) are among the main mechanisms of reasons for resistance to carbapenems. The present study aimed to evaluate the patterns of antibiotic resistance and the prevalence of carbapenemase genes of oxacillinases in clinical isolates of A. baumannii in a hospital in Bandar Abbas, Iran. Methods: A total of 69 isolates of Acinetobacter were collected within two years from different samples of patients’ bodies in the Shahid Mohammadi Hospital of Bandar Abbas. The isolates genus was identified using biochemical methods and A. baumannii species using PCR. Antibiotic resistance to imipenem and meropenem was identified through disk diffusion method. OXA-type carbapenem resistance genes were identified by multiplex PCR. The data were statistically analyzed through the chi-square test using SPSS 17, and the graphs were plotted using Excel. Results: Out of 69 Acinetobacter isolates, 57 (82.6%) had blaOXA-51 gene and were identified as A. baumannii. Antibiogram showed a significant resistance to beta-lactams and other antibiotics studied. The resistance percentage of the isolates to imipenem and meropenem antibiotics were 29.8% and 70.2%, respectively. Although all isolates were susceptible to colistin and polymyxin B, 78.9% of isolates had blaoxa-23, 8.8% blaOXA-24, and 1.7% blaOXA-58 genes. Conclusion: This study showed that beta-lactamase OXA-23 gene is the common identified known carbapenemase among carbapenem-resistant A. baumannii in Bandar Abbas Hospital. Evaluation of antibiotic-resistant genes in A. baumannii is necessary to further control dissemination of antibiotic resistance genes
similar resources
Distribution and antibiogram pattern of Acinetobacter infections in Shahid Mohammadi Hospital, Bandar Abbas, Iran
Introduction: Acinetobacter species are important opportunistic pathogens, widely spread in hospitals' environment and responsible for different health care associated infections. Because of its ability to rapidly develop resistance to the major groups of antibiotics, treatment of Acinetobacter infections is difficult and antibiotic susceptibility tests can help in choosing the best antibiotics...
full textAnalyzing ordering schedule of blood and its products in Shahid Mohammadi hospital, Bandar Abbas, Iran
Introduction: Supplying healthy blood and blood products for patients is amongst the high-priority goals of every country in the world. It is evident that meeting this goal needs a large organization with ideal human resources and equipments. Improper ordering of blood by hospitals and medical centers not only increases the Iran Blood Transfusion Organization expenses, but also prevents proper ...
full textMolecular epidemiology of Blastocystis sp. isolates in Bandar Abbas, South of Iran
Background and Objective: Blastocystis sp. is an anaerobic, single-celled intestinal parasite with global prevalence that is found in the lower digestive tract of humans and many animals, such as numerous types of vertebrates. To date, 17 genotypes have been identified. Nine of these genotypes are common in humans. Organism is found in both healthy and compromised individuals, hence its pathoge...
full textMolecular Investigation of Resistance to Disinfectants in Acinetobacter Baumannii Isolates Collected From Qazvin Hospitals, Iran (2017)
Background Acinetobacter baumannii is an important agent of nosocomial infections. There are several reports on the presence of disinfectants-resistant Acinetobacter baumannii developed by qacE and qacEΔ1 genes in medical centers. Objective The current study aimed to assess the relevant antimicrobial susceptibility and to determine the frequency of genes encoding resistance to disinfectants i...
full textPrevalence of diabetes in patients with gallstones in Shahid Mohammadi Hospital of Bandar Abbas in 2014
Introduction: Gallstone is among the most prevalent abdominal diseases worldwide which can have different covert reasons such as diabetes. The present research aimed to investigate the prevalence of diabetes among patients afflicted with a gallstone. Methods: The present descriptive, cross-sectional research was retrospective in nature and was conducted on 347 patients suffering from a gallsto...
full textSuicide Committing Trend According to Emergency Unit Records of Shahid Mohammadi Hospital in Bandar Abbas
Background: Suicide is a mental health problem. According to the world health organization report, it is the third leading cause of death in people aged 15−29 years. Materials and Methods: This descriptive study included 666 suicide cases who referred to the emergency unit of Shahid Mohammadi Hospital of Bandar Abbas, Iran during 2008-2014. The required data were analyzed with chi-square and on...
full textMy Resources
Journal title
volume 19 issue None
pages 16- 24
publication date 2015-04
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023